Aduana Stars reclaimed the top spot with a 1-0 victory over Bechem United at the Nana Agyemang Badu I Park.
Bright Adjei's first-half goal secured the win, propelling Aduana Stars to 27 points, one ahead of second-placed FC Samartex 1996.
Accra Hearts of Oak faced disappointment as Richard Danso's stoppage-time goal for Nations FC led to a 1-1 draw.
Despite Hamza Issah's early goal for Hearts of Oak, defensive lapses allowed Nations FC to equalize.
Great Olympics halted Asante Kotoko's winning streak in a goalless draw at the Baba Yara Sports Stadium.
Kotoko aimed to close the gap at the top, but the Olympics secured a crucial point.
Bibiani Gold Stars, winless in nine matches, secured a 3-0 victory against in-form FC Samartex 1996 at Duns Park.
Alex Aso's brace and Prince Owusu Kwabena's goal lifted the Gold Stars out of the relegation zone.
Bofoakwa Tano, struggling since their home ban, suffered a 1-0 defeat to Legon Cities at the Dr Kwame Kyei Sports Complex.
Kamal Suraje's first-half goal secured Legon Cities' third successive victory.
Medeama and Dreams FC couldn't participate in match week 15 due to their involvement in Africa's club competition.
The week will conclude with Accra Lions hosting Nsoatreman FC in Sogakope on Monday.
Results from week 15:
- Gold Stars FC 3-0 FC Samartex 1996
- Bofoakwa Tano 0-1 Legon Cities
- Great Olympics 0-0 Asante Kotoko
- Real Tamale United 0-1 Berekum Chelsea
- Nations FC 1-1 Accra Hearts of Oak
- Aduana Stars 1-0 Bechem United