Asante Kotoko secured a 1-0 victory over Real Tamale United (RTU) at the Baba Yara Stadium. Steven Mukwala's penalty was the decisive goal, extending Kotoko's unbeaten run.
Samartex moved to the top of the league log after defeating Karela United 3-0 at the Nsenkyire Stadium.
Hearts of Oak failed to secure a win once again, as they were held to a goalless draw by rivals Great Olympics.
Other results from the weekend:
Berekum Chelsea 0-0 Bofoakwa Tano
Dreams 1-1 Accra Lions
Nsoatreman 1-0 Aduana FC